Table 2.

Baseline clinical characteristics of the TRIBE and FIRE-3 cohorts

TRIBE cohort (N = 228)FIRE-3 cohort (N = 297)
n (%)n (%)Pa
Gender
 Male138 (61)195 (66)
 Female90 (39)102 (34)0.23
Age
 Median (range)60 (29–75)65 (31–76)<0.001
 <65163 (71)156 (53)
 ≥6565 (29)141 (47)<0.001
Performance status
 ECOG 0188 (83)163 (55)
 ECOG 1–239 (17)134 (45)<0.001
 Unknownb1 (0.4)
Primary tumor site
 Right side57 (25)63 (21)
 Left side156 (68)180 (61)0.84
 Unknownb15 (7)54 (18)
Liver limited disease
 Yes72 (32)96 (32)
 No156 (68)201 (68)0.86
Number of metastatic sites
 <299 (43)107 (36)
 ≥2129 (57)142 (48)0.92
 Unknownb48 (16)
Time to metastasis
 Synchronous188 (82)185 (62)
 Metachronous40 (18)63 (21)0.038
 Unknownb48 (16)
Primary tumor resection
 Yes144 (63)257 (87)
 No84 (37)40 (13)<0.001
Adjuvant chemotherapy
 Yes28 (12)54 (18)
 No200 (88)243 (82)0.065
KRAS status
 Wild-type96 (42)249 (84)
 Mutant93 (41)48 (16)<0.001
 Unknownb39 (17)
  • aBased on the χ2 test or the Wilcoxon rank-sum test whenever appropriate.

  • bNot included in the test.