Table 1.

Docking scores of enzalutamide (Enza), ARN-509, and RD162

Docking scores (kcal/mol)
WTF877LF877L/T878A
Enza/−10.4−15.1
ARN/−10.8−15.9
RD/−10.1−14.8
  • NOTE: Docking simulations were used to predict the affinity of the compounds (kcal/mol) according to the top solutions for the different AR mutants. Decrease of the docking score is in relation increased stability of the receptor–ligand pair.