Table 1.

List of upstream regulators related to MAPK signaling identified from pathway analysis of genes significantly modulated (>2-fold) after treatment with GS87 (30 μmol/L), Li (10 mmol/L), or SB (20 μmol/L) for 48 hours

Upstream regulatorActivation fold changeP
MAPK pathway—GS87
SB203580−5.845.43E−13
PD98059−5.2317.30E−26
U0126−4.7545.18E−15
SP600125−3.8851.92E−09
SB202190−3.0241.36E−10
MAPK102.1971.37E−04
MAPK2.2876.33E−09
MAP2K1/22.3656.66E−09
MAPK132.4044.15E−04
MAPK122.4182.17E−04
MAP3K72.4941.23E−06
MAP2K32.7601.10E−05
MAPK72.7682.01E−05
MAPK33.0561.45E−06
MAP2K13.0924.83E−10
MAPK143.4298.35E−04
MAP3K83.7652.11E−06
ERK1/23.8058.31E−11
ERK3.9618.06E−17
JNK3.9667.79E−07
MAPK pathway—SB
U0126−2.9499.97E−07
LY294002−2.6816.23E−05
PD98059−2.6622.13E−05
SB203580−2.1532.32E−04
ERK2.0001.70E−05
MAPK pathway—Li
JNK2.2214.88E−03
ERK2.5923.47E−04