EC50 valuesa (nmol/L drug) for αCD30 glucuronide-based DAR 8 ADCs
ADC cytotoxicity | CD30+ lymphoma cell lines | ||||||
---|---|---|---|---|---|---|---|
8-drugs/antibody | Linker | L540cy, HL | L428b, HL | Karpas299, ALCL | DEL, ALCL | DEL-BVRb, ALCL | Ramos (CD30−) |
αCD30–6 | glucQ-AE | 0.032 nmol/L | 0.051 | 0.010 | 0.014 | 0.17 | >100 |
αCD30–7 | gluc-MMAE | 0.086 | 0.16 | 0.015 | 0.035 | 0.72 | >100 |
αCD30–8 | glucQ-Tub | 0.053 | 0.014 | 0.016 | 0.042 | 0.20 | >100 |
αCD30–9 | gluc-DMTub | 0.27 | 1.4 | 0.18 | 0.11 | 6.0 | >100 |