Table 1.

EC50 valuesa (nmol/L drug) for free drugs following a 96-hour incubation

Free drug cytotoxicity
CompoundDrugL540cy, HLL428b, HLKarpas299, ALCL786-Ob, RCCRamos, NHL
1AE0.17 nmol/L0.240.120.810.10
2MMAE0.401.70.132.20.11
3Tub0.140.0390.110.380.090
4DMTub8.7157.7>1003.5
5TubNHNH20.720.94
  • aFollowing treatment, cells were assessed for viability as described in the Materials and Methods.

  • bMDR-positive by rhodamine efflux.