Table 1.

ABT-414 cytotoxicity in human tumor cell lines

Tumor cell lineTumor typeEGFR GenotypeCytotoxicity (nmol/L)a
A431Vulvar epidermoid carcinomaWild-type amplified8
MDA-MB-468TN breast cancerWild-type amplified12
U87MGde2-7Glioblastoma multiformeEGFRde2-7 (ectopic amplified)0.3
SCC-15HNSCCWild-type amplified21
HCC827.ER.LMCLung adenocarcinomaWild-type, E746_A750 amplified10
FaDuSquamous cell carcinoma of the hypopharynxWild-type130
A549Lung carcinomaWild-type>1,000
NCI-H1703Lung squamous cell carcinomaWild-type23
SW48Colorectal adenocarcinomaWild-type30
U87MGGlioblastoma multiformeWild-type222
NCI-H441Lung adenocarcinomaWild-type121
LoVoColorectal adenocarcinomaWild-type234
HCT15Colorectal adenocarcinomaWild-type494
NR6Mouse fibroblastsEGFR-null>1,000
NR6 EGFR wild-typeMouse fibroblastsEGFR wild-type4

Abbreviations: TN, triple-negative; HNSCC; squamous cell carcinoma of the head and neck.

  • aCell viability was determined following incubation with ABT-414 for 72 hours. The values represent IC50s. Parental ABT-806 does not inhibit growth of any of these cell lines.