Table 2.

ABT-414 growth inhibition of xenograft tumorsa

XenograftDose (mg/kg)TGImax (%)TGD (%)
A4311098>792
FaDu1079241
HCC827.ER.LMC1099>694
SCC-15179133
LoVo1095196
NCI-H17031099>546
NCI-H4411091213
SW481097494
U87MGde2-71099>792
A54910190
HCT-15102423
  • aA comprehensive summary including results from different dosing regimens is available in the Supplementary Table S2.