Table 1.

Mean pharmacokinetic parameters of BAY 1161909 and BAY 1217389 after single administration in preclinical species

Intravenous (i.v.) administrationOral (p.o.) administration
SpeciesGenderDose (mg/kg)t1/2 (h)Vss (L/kg)CLblood (L/h/kg)GenderDose (mg/kg)Tmax (h)Cmax (μg/L)F (%)
BAY 1161909
MouseM0.54.93.40.69F1.04.012059
RatM0.5142.40.19M0.54.011049
BAY 1217389
MouseF1.04.12.70.82F1.07.07437
RatM0.57.82.20.54M0.51.517773

NOTE: intravenous administration as bolus.

Abbreviations: M, male; F, female.