Table 3.

Antiproliferative activity of entrectinib on Ba/F3 cells expressing different EML4–ALK mutants

Cell linesIC50 (μmol/L)
Ba/F3+ IL32.650
Ba/F3-EML4-ALK-wt-0.028
+ IL31.490
Ba/F3-EML4-ALK-C1156Y-0.029
+ IL31.070
Ba/F3-EML4-ALK-L1196M-0.067
+ IL31.380
Ba/F3-EML4-ALK-G1202R-0.897
+ IL32.780
Ba/F3-EML4-ALK-G1269A-0.390
+ IL31.150