Table 2.

DMOT4039A exposure (cycles administered)

Every 3 weeks scheduleWeekly schedule
0.2 mg/kg (n = 3)0.4 mg/kg (n = 3)0.8 mg/kg (n = 3)1.6 mg/kg (n = 3)2.4 mg/kg (n = 36)2.8 mg/kg (n = 6)0.8 mg/kg (n = 4)1 mg/kg (n = 7)1.2 mg/kg (n = 7)
Extent of exposure to DMOT4039A
 Median # doses administered (range)4 (2–6)1 (1–6)2 (1–3)3 (2–9)3.5 (1–15)5 (2–15)6 (6–29)10 (3–23)6 (1–30)
Treatment-related dose modifications
 Drug permanently discontinued due to AE2 (6%)2 (29%)
 Dose reductions8 (22%)3 (50%)1 (14%)1 (14%)