Table 5.

Pharmacokinetic parameters for the total antibody, ac-MMAE, and unconjugated MMAE analytes in cycle 1 at 2.4 mg/kg

Cmax mean (% CV)AUC0-inf mean (% CV)CL mean (% CV)
DMOT4039A dose (mg/kg)Total Ab (μg/mL)ac-MMAE (ng/mL)Unconjugated MMAE (ng/mL)Total Ab (μg/mL/day)Total Ab (μg/mL)ac-MMAE (ng/mL)Unconjugated MMAE (ng/mL)acMMAE (mL/day/kg)
2.4 q3w (N = 36)39 (16%)746 (21%)4.2 (45%)162 (38%)1607 (22%)34 (50%)20 (31%)27 (22%)

Abbreviation: CV, coefficient of variation.