Table 1.

IC50 values in 10 NSCLC cell lines responding to PHA665752 and crizotinib

Cell linesEBC-1A549LC-2/adPC-9PC-14HCC827NCI-H441NCI-H1648ABC-1RERF-LC-MS
PathologySQACACACACACACACACAC
PHA6657520.033.53.73.94.69.417.720.533.8100
IC50 (μmol/L)
Crizotinib<0.01244.13.826.719.912.119.62027.9
IC50 (μmol/L)
MET amplification+++
KRAS mutation+++
EGFR mutation++

Abbreviations: AC, adenocarcinoma; SQ, squamous cell carcinoma.