Table 2.

Binding affinities of R3Mab and its variants to all human FGFR homologs

KD, nmol/L
FGFR1-IIIbFGFR1-IIIcFGFR2-IIIbFGFR2-IIIcFGFR3-IIIbFGFR3-IIIcFGFR4
R3MabNDNDNDND0.240.61ND
2B.1.3NDND2.62.00.090.0732
2B.1.3.10NDND2.91.10.110.25ND
2B.1.3.12NDND3.06.10.500.72ND

Abbreviation: ND, not detectable at 500 nmol/L.