Table 1.

Polyploidy and RAD51 expression infer resistance to PARP inhbition

CellsIC50 romidepsinIC50 ABT-888
Nontreated10.62 μmol/L18.95 μmol/L
Treated nonsorted8.75 μmol/L19.54 μmol/L
Polyploid sorted8.15 μmol/L27.20 μmol/L
BRCA1 reconstituted6.25 μmol/L52.13 μmol/L

NOTE: Bold text indicates enhanced resistance in this population compared to nonsorted.