Table 1A.

Associations between HSP90 expression and clinicopathologic factors in IHCC

	HSP90				HSP90
	Negative	Positive			Negative	Positive
IHCC characteristics	(n = 98)	(n = 79)	P	IHCC characteristics	(n = 98)	(n = 79)	P
Median age (range)	64.0 (35–84)	66.0 (41–84)	0.171	Perineural invasion			0.525
Sex			0.384	Negative	46	38
Male	64	49		Positive	51	41
Female	34	30		Intrahepatic metastasis			0.008^a
Preoperative CEA level			0.381	Negative	79	50
≤5.0 U/mL	75	58		Positive	19	29
>5.0 U/mL	23	21		Bile duct margin			0.063
Preoperative CA19-9 level			0.159	Negative	69	46
≤37 U/mL	38	24		Positive	29	33
>37 U/mL	59	54		UICC pathologic tumor status			0.013^a
Average tumor size			0.826	T1	10	1
cm (range)	5.1 (0.5–15.0)	5.2 (1.4–15.0)		T2	41	38
Macroscopic type			<0.001^a	T3	8	15
Non–mass forming	24	3		T4	39	25
Mass forming	74	76		Lymph node metastasis			0.032^a
Histologic classification (differentiated)			0.002^a	Negative	70	45
Mucinous and well	28	9		Positive	28	34
Moderately	69	66		UICC pathologic stage status			0.007^a
Poorly	0	4		I	10	1
Portal vein invasion			0.482	II	30	20
Negative	25	19		III	4	12
Positive	73	60		IVA + IVB	54	46
Hepatic vein invasion			0.248	c-MET			0.304
Negative	57	41		Negative	43	44
Positive	41	38		Positive	8	5
Lymphatic invasion			0.055	EGFR			0.308
Negative	66	43		Negative	40	31
Positive	32	36		Positive	13	14
Venous invasion			0.471	VEGF			0.232
Negative	55	43		Negative	25	17
Positive	43	36		Positive	28	28

NOTE: HSP90 in IHCC showed a significant association with macroscopic type (P < 0.001), histologic classification (P = 0.002), intrahepatic metastasis (P = 0.008), pathologic tumor status (P = 0.013), lymph node metastasis (P = 0.032), and pathologic stage (P = 0.007).

↵^aSignificantly different (P < 0.05).