Associations between HSP90 expression and clinicopathologic factors in IHCC
HSP90 | HSP90 | ||||||
---|---|---|---|---|---|---|---|
Negative | Positive | Negative | Positive | ||||
IHCC characteristics | (n = 98) | (n = 79) | P | IHCC characteristics | (n = 98) | (n = 79) | P |
Median age (range) | 64.0 (35–84) | 66.0 (41–84) | 0.171 | Perineural invasion | 0.525 | ||
Sex | 0.384 | Negative | 46 | 38 | |||
Male | 64 | 49 | Positive | 51 | 41 | ||
Female | 34 | 30 | Intrahepatic metastasis | 0.008a | |||
Preoperative CEA level | 0.381 | Negative | 79 | 50 | |||
≤5.0 U/mL | 75 | 58 | Positive | 19 | 29 | ||
>5.0 U/mL | 23 | 21 | Bile duct margin | 0.063 | |||
Preoperative CA19-9 level | 0.159 | Negative | 69 | 46 | |||
≤37 U/mL | 38 | 24 | Positive | 29 | 33 | ||
>37 U/mL | 59 | 54 | UICC pathologic tumor status | 0.013a | |||
Average tumor size | 0.826 | T1 | 10 | 1 | |||
cm (range) | 5.1 (0.5–15.0) | 5.2 (1.4–15.0) | T2 | 41 | 38 | ||
Macroscopic type | <0.001a | T3 | 8 | 15 | |||
Non–mass forming | 24 | 3 | T4 | 39 | 25 | ||
Mass forming | 74 | 76 | Lymph node metastasis | 0.032a | |||
Histologic classification (differentiated) | 0.002a | Negative | 70 | 45 | |||
Mucinous and well | 28 | 9 | Positive | 28 | 34 | ||
Moderately | 69 | 66 | UICC pathologic stage status | 0.007a | |||
Poorly | 0 | 4 | I | 10 | 1 | ||
Portal vein invasion | 0.482 | II | 30 | 20 | |||
Negative | 25 | 19 | III | 4 | 12 | ||
Positive | 73 | 60 | IVA + IVB | 54 | 46 | ||
Hepatic vein invasion | 0.248 | c-MET | 0.304 | ||||
Negative | 57 | 41 | Negative | 43 | 44 | ||
Positive | 41 | 38 | Positive | 8 | 5 | ||
Lymphatic invasion | 0.055 | EGFR | 0.308 | ||||
Negative | 66 | 43 | Negative | 40 | 31 | ||
Positive | 32 | 36 | Positive | 13 | 14 | ||
Venous invasion | 0.471 | VEGF | 0.232 | ||||
Negative | 55 | 43 | Negative | 25 | 17 | ||
Positive | 43 | 36 | Positive | 28 | 28 |
NOTE: HSP90 in IHCC showed a significant association with macroscopic type (P < 0.001), histologic classification (P = 0.002), intrahepatic metastasis (P = 0.008), pathologic tumor status (P = 0.013), lymph node metastasis (P = 0.032), and pathologic stage (P = 0.007).
↵aSignificantly different (P < 0.05).