Table 4.

PD-L1 expression in primary versus metastasis

Tumor histologyDetection antibodyPrimary lesion (% tumor cells positive for PD-L1)Metastatic lesion (% tumor cells positive for PD-L1)CommentReferences
RCC5H144%43%Unmatched (different patient) primary and metastatic samples(77)
405.9A1130%27%Matched (same patient) primary and metastatic samples(66)
Melanoma5H135%43%Unmatched (different patient) primary and metastatic samples(54)
TNBCNR100%92%Matched (same patient) primary and metastatic samples(95)

Abbreviations: H-score, immunoreactivity score: (3 × percentage of strongly staining tumor cells) + (2 × percentage of moderately staining tumor cells) + (percentage of weakly staining tumor cells), range of 0 to 300; NR, not reported.