Table 3.

Overview of relevant literature concerning the prognostic value of CTCs in patients with pBC treated with NAC

DetectionBloodvolume% CTC-positive patientsCorrelation
ReferenceTrialplatform(mL)nPre NACPost NACwith pCRDMFSOS
Pierga et al. (5)REMAGUS02CellSearch7.511523%17%NoHR 5.0 (95% CI, 1.4–17; P = 0.01) after 36 months FUHR 9.0 (95% CI, 1.8–45; P = 0.007) after 36 months FU
Bidard et al. (6,7)HR 2.4 (95% CI, 0.9–6; P = 0.06) after 70 months FUHR 3.0 (95 CI, 1.0–9.5; P = 0.05) after 70 months FU
Riethdorf et al. (2)GeparQuattroCellSearch7.528722%11%NoNRNR
Azim et al. (18)NeoALLTOCellSearch after Ficoll density gradient separation22.55111%13%NoNRNR

Abbreviations: HR, hazard ratio; CI, confidence interval; FU, follow-up; DMFS, distant metastasis-free survival; NR, not reported.