Table 2.

Cellular activity of AMG 232 in tumor cell lines

Cell linep21 IC50 (nmol/L)ap21 max. fold inductionProliferation IC50 (nmol/L)a
SJSA-146.8 ± 14.5 (n = 10)34.90 ± 4.09 (n = 10)9.4 ± 2.9 (n = 69)
HCT11620.8 ± 9.7 (n = 8)9.76 ± 2.10 (n = 8)11.3 ± 6.0 (n = 9)
ACHN12.8 ± 6.0 (n = 4)11.45 ± 1.36 (n = 4)23.8 ± 5.3 (n = 4)

NOTE: Data represent mean ± SEM. n = number of assays conducted.

  • aAssays were conducted in the presence of 10% human serum.