Table 1.

Approximate IC50 values for MLN0128 in 20 bone and soft-tissue sarcoma subtypes are shown

Cell lineIC50
RMS
 A2042 nmol/L
 SMS-CTR4 nmol/L
 SK-RMS -36 nmol/L
 RD8 nmol/L
 Rh289 nmol/L
 RMS-55915 nmol/L
 Rh3028 nmol/L
 TE-38130 nmol/L
 SK-RMS -470 nmol/L
Ewing sarcoma
 TC-716 nmol/L
 CHLA97 nmol/L
 CHP10064 nmol/L
 TC-3217 nmol/L
 A673130 nmol/L
MPNST
 MPNST25 nmol/L
 ST881425 nmol/L
Leiomyosarcoma
 SKLMS29 nmol/L
Osteosarcoma
 SaOS-214 nmol/L
Liposarcoma
 LS14153 nmol/L
Synovial sarcoma
 SYO-182 nmol/L