Table 1.

Potency of AZD8186 in biochemical and cell based assays

Biochemical assayIC50μmol/L ± SEM (n)Cell isoform selectivity: cell lineModulation of pAKT IC50μmol/L ± SEM
PI3Kα0.035 ± 0.005PI3Kα: BT4740.752 ± 0.293
PI3Kβ0.004 ± 0.001PI3Kβ: MDA-MB-4680.003 ± 0.001
PI3Kδ0.012 ± 0.002PI3Kδ: JEKO0.017 ± 0.004
PI3Kγ0.675 ± 0.114PI3KγNT