Table 1.

Sensitivity of TNBC cell lines to mesothelin-targeted RITs

HCC70SUM149
RITIC50 (ng/mL)IC50 (pmol/L)nIC50 (ng/mL)IC50 (pmol/L)n
SS1P4.6 ± 3.274.1 ± 52.0915.7 ± 9.8252 ± 1583
SS1-LR0.94 ± 0.5619.6 ± 11.751.5 ± 1.430.2 ± 29.12
RG77873.4 ± 2.845.2 ± 37.9104.8 ± 1.364.8 ± 17.93

NOTE: Sensitivity of HCC70 and SUM149 TNBC cell lines is reported in IC50 values ± SD for SS1P, SS1-LR, and RG7787 RITs. n = number of times each experiment was repeated with six replicates in each experiment.