Table 2.

Sensitivity of gastric cell lines to RITs

Sites/cellIC50 (ng/mL)IC50 (pmol/L)
Sample(×103)SS1PRG7787SS1PRG7787
MKN75.62.3>10037.1>1,200
MKN2816.10.345.65.575.6
MKN459.92.30.537.16.8
MKN744.22.31237.1162.0

NOTE: Surface mesothelin for MKN7, MKN28, MKN45, and MKN74 gastric cancer cell lines was determined by flow-cytometric assay and standardized to determine sites per cell as described in Materials and Methods. WST-8 assay was used to determine IC50 of these cell lines to the SS1P and RG7787 RITs.