Table 1.

Patient characteristics

All patientsCohort 1Cohort 2
N = 158 (%)n = 86n = 72P
Gender
 Male80 (51)49 (57)31 (43)0.08
 Female78 (49)37 (43)41 (57)
Age, ya
 Mean (SD)63 (10)63 (10)62 (9)0.44
 Range25–7932–7925–75
 >Mean95 (60)54 (63)41 (57)
 ≤Mean63 (40)32 (37)31 (43)
ECOG PSb
 091 (58)54 (63)37 (53)0.21
 1–265 (42)32 (37)33 (47)
Tumor resection
 Yes92 (58)40 (47)52 (72)
 No66 (42)46 (53)20 (28)0.001
Localization
 Colon100 (63)56 (65)44 (61)0.29
 Rectum56 (35)30 (35)26 (36)
 Synchronous2 (1)0 (0)2 (3)
Metastatic organ sitesb
 182 (53)45 (52)37 (53)0.95
 ≥274 (47)41 (49)33 (47)
Adjuvant chemotherapyb
 Yes13 (8)4 (5)9 (13)0.07
 No144 (92)82 (95)62 (87)
KRASb
 Wild-type43 (48)22 (54)21 (44)0.35
 Mutated46 (52)19 (46)27 (56)
RRc
 Response71 (47)40 (49)31 (45)0.64
 Nonresponse79 (53)41 (51)38 (55)
PFS
 Median (mo, 95% CI)8.4 (7.5–9.3)8.0 (6.7–9.4)8.6 (7.7–9.5)0.34

Abbreviation: ECOG PS, Eastern Cooperative Oncology Group performance status.

  • aAge at start of treatment.

  • bData registration incomplete.

  • cEight patients were not evaluable according to RECIST.