Table 1.

IC50 values after 5 days of cyclopamine, CGP-2, or temozolomide treatments

IC50 values of cyclopamineIC50 values of CGP-2IC50 values of temozolomide
GIC-224 μmol/L (±1.5)25 μmol/L (±0.2)474 μmol/L (±47)
GIC-333 μmol/L (±1.9)26 μmol/L (±1.8)787 μmol/L (±54)
GIC-629 μmol/L (±1.6)29 μmol/L (±3.9)830 μmol/L (±40)
GIC-1224 μmol/L (±3.2)27 μmol/L (±4.6)864 μmol/L (±1.7)

NOTE: IC50 values of cyclopamine and CGP-2 were much lower than temozolomide IC50 values. IC50 values were calculated as the mean drug concentration required for inhibiting cell proliferation by 50% compared with control (mean ± SD).