Table 1.

Kinase inhibition assay against TGFβRI and p38α

IC50 (nmol/L)
CompoundALK5P38aSelectivity index
EW-719712.91,775138
IN-113013.028822
SB-50512426.864024

NOTE: IC50 values of the compound against TGFβRI and p38α were measured using a radiometric protein kinase assay (33ProQinase Activity Assay; ProQinase), which is described in the Supplementary Materials and Methods.