Table 1.

IC50 values of MOG-19 and MOG-13

MOG-19MOG-13
TargetAV(nmol/L)(nmol/L)
Receptors
 FLT318132
 VEGFR-27037
Signaling cascade
 GSK3β71>10.000

NOTE: IC50 values of MOG-19 and MOG-13 were carried out at Millipore (http://www.millipore.com/life_sciences/flx4/ld_kinases) by a kinase assay (in nmol/L). MOG-19 is known as a potent VEGFR-2/3 inhibitor (IC50: 70/5 nmol/L) as well as FLT3 and GSK3β inhibitor and a moderate PDGFRβ inhibitor (IC50, 680 nmol/L). With the exception of GSK3β, the same is true for MOG-13.