Table 1.

Effect of PKD inhibitors on cell proliferation

PKD inhibitor IC50 (μmol/L)
Cell linesCRT0066101kb-NB142-70CID755673
RKO0.90 ± 0.172.82 ± 0.6724.68 ± 5.50
HCT116 (p53+/+)0.77 ± 0.252.69 ± 0.0715.51 ± 2.55
HCT116 (p53−/−)1.01 ± 0.063.08 ± 0.3817.52 ± 1.80
H6301.28 ± 0.184.33 ± 2.1846.7 ± 27.65
H630R11.56 ± 0.348.35 ± 4.3135.28 ± 5.42

NOTE: IC50 values represent the concentration of drug that suppressed cell growth by 50%. Values represent the mean ± SD from 3 to 5 determinations.