Table 1.

Drug sensitivities of various breast cancer cell lines

Cell lineMGMT statusIC50 TMZ (μmol/L)IC50 T-P (μmol/L)Differential (-fold)
MDA-MB-231-br3.81.23.2
MDA-MB-2319.92.34.3
T47D204.64.3
HCC-1937+186316.0
MDA-MB-468+195316.3
MCF7+5133315.5

NOTE: Shown are IC50 values (i.e., drug concentrations that reduce colony-forming ability by 50%) and differential toxicity between T-P and TMZ (i.e., fold increased potency of T-P over TMZ).