Table 1.

IC50 values of cell lines treated with imipramine-blue

Cell lineCancer/cell type (viral infection)IC50 24-hour imipramine-blue/(95% CI), μmol/LIC5072-hour imipramine-blue/(95% Cl), μmol/L
FLP1Fibroblast cell line7.70/(6.57–9.04)7.16/(6.13–8.37)
HEK-293WTEmbryonic kidney (HAdV-5+)4.11/(3.49–4.84)2.36/(2.24–2.50)
HeLaCervix carcinoma (HPV18+)3.92/(3.41–4.49)2.02/(1.83–2.23)
MDA-MB-231Breast carcinoma1.91/(1.64–2.22)1.11/(0.88–1.40)
AS-MAngiosarcoma1.81/(1.56–2.10)0.98/(0.91–1.06)
SH-SY5YNeuroblastoma1.74/(1.17–2.58)1.79/(1.13–2.84)
SMS-KANNeuroblastoma1.60/(0.97–2.64)1.17/(0.61–2.24)
KELLYNeuroblastoma0.78/(0.52–1.17)0.14/(0.11–0.18)
BL41B95aBurkitt lymphoma (EBV+)1.11/aD0.78/aD
BL30B95aBurkitt lymphoma (EBV+)0.79/aD0.47/(0.31–0.70)
BL2aBurkitt lymphoma0.49/(0.42–0.57)0.75/aD
BL2B95aBurkitt lymphoma (EBV+)0.16/(0.13–0.21)0.45/(0.35–0.59)

NOTE: IC50 values were calculated on the basis of methyl violet assay data; IC50 is the concentration that inhibits 50% of proliferation; aD is the ambiguous data, which means no reliable calculation of 95% CIs was possible.

  • aIC50 values calculated on the basis of MTT cell viability assay data instead of the methyl violet assay.