Table 1.

Binding affinities of 1 (UMI-59) and 2 (UMI-77) to five antiapoptotic Bcl-2 family members in competitive FP assay using fluorescent-labeled Bid BH3 peptide

Ki ± SD, μmol/L
Protein1 (UMI-59)2 (UMI-77)
Mcl-11.55 ± 0.180.49 ± 0.06
A1/Bfl-16.14 ± 1.05.33 ± 1.0
Bcl-254.65 ± 9.5623.83 ± 1.81
Bcl-xL99.0 ± 22.6332.99 ± 4.33
Bcl-w37.53 ± 7.968.19 ± 1.91