Table 1.

Cytotoxicity of docetaxel

Cell linesSNCG expression statusCytotoxicity IC50
MCF-7Negative27
MCF-S6Transfected89
MDA-MB-435Negative63
SNCG-435-3Transfected153
T47DPositive68
AS-3Knockdown29

NOTE: Stable SNCG-transfected MCF-7 (MCF-S6), MDA-MB-435 (SNCG-435-3), and SNCG knockdown T47D (AS-3) cells were previously established. All six cell lines were treated with docetaxel (ranging from 10 to 250 nmol/L) for 24 hours. Cytotoxicity was measured by the MTT assay. The IC50 values were defined as the concentration of drug eliciting 50% cell killing and determined by regression analysis.