Table 1.

Subtypes and molecular status of breast cancer cell lines

ExpressionMutation
Cell linesSubtypeARERPRHER2PTENPTENPI3KCAp53
MCF-7aLuminal A++++WTE545KWT
MDA-MB-453aUnclassified+++E307KH1047RDeletion
SKBR3aHER2+++WTH1047RR175H
BT-474aLuminal B+++++WTK111NE285K
MDA-MB-468TNA72fs X5WTR273H
BT20Basal+WTP539RK132Q
H1047R
MDA-MB-436TNWTWT205 fs
MDA-MB-231TN+WTWTR280K
AU565HER2++WTWTR175H
HCC1395Basal+N212fsWTR175H

Abbreviation: TN, triple negative.

  • aNVP-BEZ235 sensitive with cell death.