Subtypes and molecular status of breast cancer cell lines
| Expression | Mutation | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Cell lines | Subtype | AR | ER | PR | HER2 | PTEN | PTEN | PI3KCA | p53 |
| MCF-7a | Luminal A | + | + | + | − | + | WT | E545K | WT |
| MDA-MB-453a | Unclassified | + | − | − | + | + | E307K | H1047R | Deletion |
| SKBR3a | HER2 | + | − | − | + | + | WT | H1047R | R175H |
| BT-474a | Luminal B | + | + | + | + | + | WT | K111N | E285K |
| MDA-MB-468 | TN | − | − | − | − | − | A72fs X5 | WT | R273H |
| BT20 | Basal | − | − | − | − | + | WT | P539R | K132Q |
| H1047R | |||||||||
| MDA-MB-436 | TN | − | − | − | − | − | WT | WT | 205 fs |
| MDA-MB-231 | TN | − | − | − | − | + | WT | WT | R280K |
| AU565 | HER2 | − | − | − | + | + | WT | WT | R175H |
| HCC1395 | Basal | − | + | − | − | − | N212fs | WT | R175H |
Abbreviation: TN, triple negative.
↵aNVP-BEZ235 sensitive with cell death.