Camptothecin | 1 | ||||||

LMP776 | 0.91 | 1 | |||||

LMP400 | 0.80 | 0.92 | 1 | ||||

Etoposide | −0.37 | −0.15 | −0.05 | 1 | |||

Doxorubicin | −0.16 | 0.06 | 0.18 | 0.73 | 1 | ||

ICRF-193 | −0.48 | −0.26 | −0.19 | 0.76 | 0.54 | 1 | |

Paclitaxel | 0.02 | 0.02 | 0.02 | −0.004 | −0.19 | 0.02 | 1 |

Camptothecin | LMP776 | LMP400 | Etoposide | Doxorubicin | ICRF-193 | Paclitaxel |

NOTE: Pearson correlation coefficients were computed for all tested topoisomerase inhibitors across the DT40 DNA repair mutant panel as shown in Fig. 1. For *n* = 50, a Pearson coefficient of less than 0.451 corresponds to a significance probability of less than 0.001 (two-tailed test). Paclitaxel is shown as negative control (see Supplementary Fig. S4).