Table 1.

IC50 values of USP1 inhibitor C527 for the indicated DUB enzymes

DUBsIC50 (μmol/L)
USP10.88 ± 0.07
USP12/465.97 ± 0.37
USP51.65 ± 0.42
UCH-L1>10
UCH-L32.18 ± 0.69