Table 1.

Calculated IC50 of HSA primary cell isolates and DNSTEC to small-molecule inhibitors

CI-1040 (μmol/L)Sorafenib (μmol/L)LY294002 (μmol/L)
SubtypesCell isolateIC50IC50IC50
VisceralVCT122.7 ± 1.51.7 ± 1.324.1 ± 1.7
VCT613.0 ± 0.33.9 ± 2.929.7 ± 5.2
VCT752.4 ± 0.11.5 ± 0.616.2 ± 4.5
CutaneousVCT393.3 ± 1.12.8 ± 1.413.1 ± 2.3
VCT623.6 ± 2.65.8 ± 2.78.8 ± 3.4
VCT1151.7 ± 0.72.4 ± 0.59.4 ± 2.9
CardiacVCT447.6 ± 5.64.0 ± 0.222.6 ± 4.2
VCT1426.5 ± 4.42.3 ± 0.39.2 ± 4.0
DNSTEC>10 μmol/L7.9 ± 3.214.7 ± 7.9