Table 2.

The changes of Bcl-2 family proteins by TH-302 and bortezomib in multiple myeloma cells

MemberPro/antiapoptoticBortezomibTH-302Bortezomib+TH-302
Bcl-2AntiapoptoticDownregulationDownregulationDownregulation
Bcl-xLAntiapoptoticNo changeDownregulationDownregulation
Mcl-1AntiapoptoticUpregulation, cleavageDownregulation, cleavageDownregulation, cleavage
BAXProapoptoticNo changeNo changeNo change
BADProapoptoticCleavageCleavageCleavage
BIDProapoptoticCleavageCleavageCleavage
PUMAProapoptoticUpregulationUpregulationUpregulation
NOXAProapoptoticUpregulationUpregulationUpregulation