Table 1.

Group mean (±SD) pharmacokinetic parameters of total antibody after a single intravenous administration of DCDT2980S to SCID mice and multiple (q3w x 5) intravenous administrations of DCDT2980S to cynomolgus monkeys

Cynomolgus monkey (q3w x 5)
Mouse (single dose)First doseLast dose
Dose (mg/kg)Cmax (μg/mL)AUCinf (μg*day/mL)Cmax (μg/mL)AUC0–21 (μg*day/mL)Cmax (μg/mL)AUC84–105 (μg*day/mL)
1NANA24.9 ± 2.9762.9 ± 6.0626.9 ± 1.1376.8 ± 7.52
3NANA87.8 ± 11.0259 ± 24.1108 ± 13.4400 ± 51.8
5134821134 ± 18.1388 ± 39.6159 ± 13.2628 ± 71.6
0.511.172.1NA
4 (estimated)NA628 ± 71.6NA

Abbreviations: q3w x 5, every 3 weeks for 5 doses; NA, not available.