Table 2.

FGFR3 mutation analysis of tumor samples and urothelial carcinoma cell lines

Tumor samples
Low gradeHigh gradeTotal
Noninvasive28/50 = 56%2/18 = 11%30/68 = 46%
Invasive4/7 = 57%10/95 = 11%14/102 = 22%
Total32/57 = 56%12/113 = 11%44/170 = 26%
Exon 7 mutation: 31 (70%)Exon 10 mutation: 13 (30%)
ExonNucleotide position/base changeCodon/change in amino acidn
7746 C > GS249C31
101114 G > TG372C4
101117 A > TS373C1
101124 A > GY375C7
101156 T > CF386L1
Cell lines
Cell lineExon 7Exon 10Cell lineExon 7Exon 10
253J-PwtwtUM-UC7wtwt
253J-BVwtwtUM-UC10wtwt
RT4 v6wtwtUM-UC11wtwt
RT112wtwtUM-UC12wtwt
T24wtwtUM-UC13wtwt
UM-UC1wtwtUM-UC14S249Cwt
UM-UC3wtwtUM-UC15S249CY375C
UM-UC4wtwtUM-UC16S249Cwt
UM-UC5wtwtUM-UC17S249Cwt
UM-UC6R248Cwt