Table 1.

Summary of combination matrices for navitoclax and G-963 in NSCLC cell lines

Cell lineAvg. Bliss sumSD of Bliss sumAvg.% inhibition of combination (navitoclax 3.3 μmol/L and G-963 3.3 μmol/L)SD of % inhibition of combination% Inhibition of G-963 (3.3 μmol/L)SD of % inhibition of G-963% Inhibition of navitoclax (3.3 μmol/L)SD of % inhibiton of navitoclaxG-963 IC50 (μmol/L)SD of G-963 IC50Navitoclax IC50 (μmol/L)SD of navitoclax IC50KRASEGFRPIK3CAPTEN
LXFL52975636791.85.631.19.645.510.3NANANANAWTWT542E > KWT
H115567428899.80.035.16.499.50.1NANA0.760.5161Q > HWTWTnull
A42757220799.10.157.82.688.47.20.430.131.180.3912G > DWTWTWT
Hop1856833885.31.336.16.834.88.2NANANANA12G > CWTWTWT
H29255928493.67.362.216.547.324.20.030.04NANAWTWTWTWT
H199350211998.90.683.06.063.721.30.090.070.830.90WTWTWTWT
H212244446788.72.069.613.617.78.60.540.61NANA12G > CWTWTWT
Calu-64387294.02.688.43.137.69.10.020.004NANA61Q > KWTWTWT
H15684006993.41.538.411.072.310.1NANA1.760.49WTWTWTWT
H16503749683.42.217.88.954.22.2NANANANAWTDEL.745KELREA > KWTnull
H35831418786.87.071.53.114.616.70.120.10NANA12G > CWTWTWT
H197527610283.25.163.36.644.85.60.210.11NANAWT790T > M, 858L > R118G > DWT
H232712889.95.669.76.148.815.80.040.04NANA12G > CWTWTWT
H12992365960.55.855.74.82.02.70.610.97NANAWTWTWTWT
H44122515671.117.932.68.036.018.8NANANA12G>VWTWTWT
A54920117193.13.771.519.046.516.50.150.17NANA12G > SWTWTWT
H200918010585.62.874.69.211.77.50.100.13NANA12G > AWTWTWT
SW15731677363.810.916.36.436.54.5NANANANA12G > CWTWTWT
Hop6297951.25.144.00.16.44.2NANANANA12G > CWTWTWT
H520678439.25.116.922.221.35.2NANANANAWTWTWTnull
H322.T532467.92.149.22.016.813.4NANANANAWTWTWTWT
H522525925.015.117.26.32.12.0NANANANAWTWTWTWT
H17033612132.76.31.31.924.01.6NANANANAWTWTWTWT
H460209035.54.032.93.40.91.6NANANANA61Q > HWT545E > KWT
SK-MES-1189966.312.336.89.318.65.2NANANANAWTWTWTWT
H838213337.86.132.44.98.40.8NANANANAWTWTWTWT
H596−44663.84.330.89.036.42.3NANANANAWTWT545E > KWT
H661−812465.88.135.46.325.72.7NANANANAWTWTWTWT
EBC-1−948091.04.472.62.987.55.70.040.010.060.02WTWTWTWT
H647−1727569.04.826.22.348.59.3NANANANA13G > DWTWTWT
Hop92−2063676.118.750.32.868.328.3NANANANAWTWTWTWT

NOTE: The data reflect the average of 3 independent runs conducted in quadruplicate.

Abbreviations: NA, not applicable; WT, wild-type.