Table 2.

CC50 values of L002 against HMEC and various cancer cell lines

Cell lineTissue/cancer typeCC50 (μmol/L)
HMECNormal>15.53a
MDA-MB-231TNBC1.03
MDA-MB-468TNBC2.57
MDA-MB-436TNBC2.85
MDA-MB-435STNBCb1.91
MCF7Breast cancer (luminal)21.67
ZR-75-1Breast cancer (luminal)8.91
SK-BR-3Breast cancer (luminal)11.6
LNCaPProstate cancer3.54
PC-3Prostate cancer4.74
DU 145Prostate cancer3.75
MIA PaCa-2Pancreatic cancer21.7
HPACPancreatic cancer>30a
BxPC3Pancreatic cancer18.56
PANC-1Pancreatic cancer8.44
HCT 116Colon cancer7.40
DLD-1Colon cancer8.35
A549Non–small cell lung cancer>30a
SH-SY5YNeuroblastoma0.19
  • aCell growth inhibition did not surpass 50% at the highest concentration tested.

  • bAlthough this cell line was isolated from the pleural effusion of a patient with breast cancer and has a gene expression profile consistent with a breast cancer origin, some studies showed that it exhibits properties indicative of a melanoma origin.