Table 1.

Growth inhibitory effect of saracatinib

Cell lineMolecular alterationIC50, μmol/L
Saracatinib
SNU216HER2 amp0.18 ± 0.01
NCI-N87HER2 amp0.76 ± 0.04
SNU1KRAS mt5.46 ± 0.28
SNU5MET amp>10
SNU16FGFR2 amp>10
SNU601KRAS mt>10
SNU620>10
SNU638MET amp>10
SNU668KRAS mt>10
SNU719>10

NOTE: The IC50 values of saracatinib determined using an MTT assay as described in Materials and Methods are shown.

Abbreviations: amp, amplification; mt, mutation.