Table 1.

TP53 somatic mutations and allelic expression

SampleTP53 tumor SNVsSNV freq. tumor DNASNV freq. RNADNA LOH
mTNBC1None detectedNANAYes
mTNBC2K320X40%100%Yes
mTNBC3R273Ha50%92%Yes
mTNBC4Exon2 splice50%N/AYes
mTNBC5NoneNANANo
mTNBC6NoneNANAYes
mTNBC7E339X47%57%No
mTNBC8L111Ra23%85%No
mTNBC9H193R53%83%Yes
mTNBC10R81X13%20%Yes
mTNBC11None detectedNANANo
mTNBC12R273Ha21%92%No
mTNBC13Y220C80%85%Yes
mTNBC14R273H21%92%No

Abbreviation: NA, not available.

  • aNot detected by mutation caller although DNA evidence below the calling threshold was found in mTNBC8, mTNBC3, and mTNBC12.