Table 1.

Production of metastasis by SCLC cells expressing high level of Dll4 with or without Dll4-Fc in NK cell–depleted SCID mice

No. of metastatic coloniesa
Cell lineIncidenceLiver weight (g)LiverKidneyLymph node
SBC-3-vector7/72.6 (1.6–5.4)15.6 (2–43)4.0 (0–11)2.1 (1–3)
SBC-3-Dll4-Fc9/91.3 (1.1–1.5)b4.0 (1–8)c2.8 (0–5)2.0 (1–3)
No. of metastatic coloniesa
Cell lineIncidenceLiver weight (g)LiverKidneyBone
H1048-vector6/61.1 (0.8–1.4)4.8 (2–7)59.8 (39–77)9.5 (8–12)
H1048-Dll4-Fc7/70.8 (0.6–1.1)1.6 (1–3)d49.9 (19–84)7.7 (3–14)

NOTE: The statistical significance of difference was analyzed by one-way ANOVA and post hoc pairwise comparisons were done by Newman–Keuls multiple comparison test.

  • aValues are the mean (minimum−maximum).

  • bStatistically significant difference compared with SBC-3-vector (P < 0.05).

  • cStatistically significant difference compared with SBC-3-vector (P < 0.001).

  • dStatistically significant difference compared with H1048-vector (P < 0.05).