Table 2.

Fold changes in protein expression following single-agent and combination treatment in A549 NSCLC cells using reverse-phase protein array analysis

Ganetespib (IC30)BEZ235 (IC30)Combination
S6 (pS240/S244)−1.28−6.80−9.07
S6 (pS235/S236)−1.70−6.86−7.66
p70S6K−1.38−1.54−1.72
4E-BP1 (pS65)1.13−1.54−1.66
YB-1 (pS102)−1.25−1.03−1.46
YB-11.02−1.03−1.41
BIM1.141.00+1.31