Table 1.

Human breast cancer cell lines characteristics and AS703569 IC50 (μmol/L)

Cell linesERPRHER2p53IC50 (μmol/L)
Triple negative
 MDA-MB468negnegnegmut0.004
 MDA-MB231negnegnegmut0.240
 HCC1143negnegnegmut0.694
 HCC 1395negnegnegmut0.277
 HCC38negnegnegmut0.572
 HBCx-8negnegnegwt0.060
 HBCx-17anegnegnegmut0.055
 HBCx-15negnegnegmut0.550
ER+/PR+ or HER2+
 HCC1419negneg+++mut7.37
 HCC2218negneg+++wt6.85
 MDA-MB361pospos++wt2.96
 BT474pospos+++mut3.60
 MCF-7pospos+/−wt4.08
 SKBR-3negneg+++mut2.52
 ZR75-1pospos++wt5.31

Abbreviations: mut, mutated; neg, negative; pos, positive.

  • aBRCA2-mutated.