Table 1.

Pharmacokinetic parameters of AMG 212/BAY2010112 after i.v. and s.c. administration to BALB/C mice

Administrationi.v. boluss.c. bolus
Dose(mg/kg)0.100.301.00.30
AUC(mg h/L)0.330.933.30.17
AUCnorm(kg h/L)3.33.13.30.55
CLmatrix(L/h/kg)0.300.320.30n.a.
Cmax norm(kg/L)10.4119.50.21
Vss(L/kg)0.891.20.94n.a.
t1/2(h)6.59.77.911
F (bioavailability)(%)10010010018

NOTE: Serum levels of AMG 212/BAY2010112 after single bolus i.v. administration of 0.1, 0.3, and 1 mg/kg and after single bolus s.c. administration of 0.3 mg/kg to female BALB/c mice were determined as described in Materials and Methods.

Abbreviations: AUC, area under the curve; AUCnorm; normalized AUC; CLmatrix, serum clearance; Cmax norm, maximum serum levels; Vss, volume of distribution at steady state; t1/2, terminal serum half-life (beta); n.a., not applicable.