Table 1.

In vitro cytotoxicity values of ganetespib in KRAS-mutant NSCLC lines

Cell lineKRAS mutationGanetespib IC50, nmol/L
H1355G13C5
H157G12R7
H460Q61H8
IA-LMG12C10
HOP-62G12C11
H23G12C11
H2030G12C12
H441G12V14
H2212G12C17
SK-LU-1G12D18
H2009G12A19
H1792G12C20
COR-L23G12V22
H727G12V28
H1734G13C28
H358G12C29
A549G12S43
H2122G12C53
Calu-1G12C58
Calu-6Q61K64