Table 1.

Severity and incidence of hyperplastic lesions in mice treated with BRAF inhibitor (PF-04880594) and MEK inhibitor (PD-0325901)

CompoundTissuesa incidence/total mice per group (severity)
GroupPD-0325901PF-04880594EsophagusTongueFeet
100
20104/6 (1,2)4/6 (1)2/6 (1)
310
40.510
50.310
60.1104/6 (1–2)
70204/6 (2–3)4/6 (2–3)4/6 (2–3)
82.520
91.020
100.320
110405/6 (2–3)6/6 (2–3)6/6 (2–3)
122.540
13140
140.340
  • aTissues positive for hyperplasia are denoted as a/b (c), in which a = the number of hyperplasia positive mice, b = the total number of mice examined per group, and c = the severity. Severity of lesions is described as 1, minimal, 2, mild, 3, moderate, and 4, severe.