Table 1.

IC50 values for complex 3 in various human cancer cell lines when irradiated with UV light λmax = 366 nm (0.216 J/cm2) or white light (in parentheses; 1.17 J/cm2) for 30 minutes at 37°C

Cell lineIC50 value (μmol/L) ± SDCell lineIC50 value (μmol/L) ± SDCell lineIC50 value (μmol/L) ± SD
563730.7 ± 5.0 (69.27 ± 7.2)aKyse 51052.9 ± 4.0RT-4136.9 ± 55.0
5637-OXOb33.0 ± 8.51 [1.08]cKyse 52066.2 ± 8.7RT-11228.6 ± 3.0
SISO43.4 ± 23.7 (59.15 ± 4.52)aLCLC-103 H38.8 ± 14.2A-42740.6 ± 8.3 (61.8 ± 31.62)a
SISO-OXOb38.1 ± 15.7 [0.88]cMCF-762.0 ± 13.2DAN-G68.2 ± 22.6 (60.78 ± 31.6)a
Kyse 7050.5 ± 4.5YAPC57.9 ± 17.7HL6035.1 ± 8.4
Kyse 70-OXOb60.6 ± 4.1 [1.20]c

NOTE: Values are averages ± SD of 3 or more independent determinations. Cell proliferation determined by the crystal violet assay, except the HL60 line, in which the MTT assay was used.

  • aIC50 values determined for white light.

  • bResistance factors for cisplatin and oxoplatin with 5637-OXO were 2.89 and 3.42, respectively; with SISO-OXO 2.07 and 3.07, respectively; with KYSE-70-OXO 2.38 and 2.09, respectively.

  • cResistance factor = IC50 resistant/IC50 wild.