Table 1.

Microtubule polymerization kinetics with TPI-287 and taxanes, in vitro

CompoundMean ± SEM ED50a, μmol/LED50 compound/ED50 paclitaxel
TPI-2871.58 ± 0.460.53
Paclitaxel2.97 ± 0.501.00
Docetaxel3.18 ± 0.451.07
  • aThe ED50 is the amount of drug required to reduce the time required to reach Vmax of tubulin polymerization in the standard reaction mixture as described in the kit instructions. Each value is the mean of 4 reaction wells ± the SEM.